Pokemon the Movie: Mewtwo Strikes Back Evolution (DVD)

Ash, Misty, Brock, and several other Pokémon trainers travel to an island, under the pretense that they will be battling a superior Pokémon trainer, only to discover the genetically engineered Pokémon Mewtwo, created by a scientist for Giovanni of Team Rocket, is there and is planning to take over the world with other cloned Pokémon.